show Abstracthide AbstractThe Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) has attracted much attention because of the dramatic decline in population size in the past decades, which raises the concern of extinction. Exploring immune changes that occur in Yangtze finless porpoise with age is important for their protection. Here, we systematically investigated the mRNA and miRNA profiles of old, adult, and young Yangtze finless porpoises to screen for genes, pathways, and predicted miRNA-mRNA networks associated with immune system.